One of the newest and most exciting advances in treating localized periodontal disease is the development of locally delivered antibiotics. This localized antibiotic is combined with scaling and root planing to remove plaque buildup and bacteria from the infected area around the teeth. The basic premise is that concentrated amounts of active medications can be delivered to the precise site of the disease process with minimal systemic uptake of medication. One of these antibiotics is called Arestin, or minocycline hydrochloride. It has been found to deliver high concentrations of medication into the affected area.